Momokazu Gotoh Selected Research

N- (4- ((5- (hydroxy(phenyl)methyl)pyrrolidin- 2- yl)methyl)phenyl)- 4- oxo- 4,6,7,8- tetrahydropyrrolo(1,2- a)pyrimidine- 6- carboxamide

1/2021	Cardiovascular safety of vibegron, a new β3-adrenoceptor agonist, in older patients with overactive bladder: Post-hoc analysis of a randomized, placebo-controlled, double-blind comparative phase 3 study.
1/2020	Efficacy of vibegron, a novel β3-adrenoreceptor agonist, on severe urgency urinary incontinence related to overactive bladder: post hoc analysis of a randomized, placebo-controlled, double-blind, comparative phase 3 study.
1/2019	Efficacy of novel β3 -adrenoreceptor agonist vibegron on nocturia in patients with overactive bladder: A post-hoc analysis of a randomized, double-blind, placebo-controlled phase 3 study.
1/2018	Vibegron, a Novel Potent and Selective β3-Adrenoreceptor Agonist, for the Treatment of Patients with Overactive Bladder: A Randomized, Double-blind, Placebo-controlled Phase 3 Study.

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Momokazu Gotoh Research Topics

Disease

35	Neoplasms (Cancer) 05/2024 - 05/2002
35	Overactive Urinary Bladder (Overactive Bladder) 11/2022 - 01/2005
21	Lower Urinary Tract Symptoms 04/2023 - 12/2009
19	Prostatic Neoplasms (Prostate Cancer) 02/2022 - 04/2003
16	Renal Cell Carcinoma (Grawitz Tumor) 05/2024 - 12/2003
16	Stress Urinary Incontinence 07/2022 - 06/2006
15	Urinary Incontinence 04/2021 - 11/2002
15	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 05/2019 - 02/2003
13	Urinary Bladder Neck Obstruction (Bladder Neck Obstruction) 01/2023 - 01/2013
8	Pain (Aches) 01/2022 - 01/2013
6	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2020 - 05/2014
6	Hemorrhage 11/2017 - 08/2004
5	Underactive Urinary Bladder 04/2023 - 07/2010
5	Neoplasm Metastasis (Metastasis) 01/2023 - 07/2008
5	Urinary Bladder Neoplasms (Bladder Cancer) 11/2022 - 04/2009
5	Cystitis 01/2017 - 04/2014
4	Carcinoma (Carcinomatosis) 01/2021 - 04/2009
4	Nocturia 01/2019 - 09/2007
4	Inflammation (Inflammations) 01/2017 - 04/2014
4	Neural Tube Defects (Exencephaly) 02/2007 - 07/2003
3	Margins of Excision 01/2019 - 05/2014
2	Body Weight (Weight, Body) 07/2022 - 11/2016
2	Prostatitis 01/2022 - 01/2020
2	Pelvic Pain 01/2022 - 01/2020
2	Constipation 12/2020 - 09/2007
2	Hypertrophy 08/2020 - 09/2009
2	Disease Progression 11/2019 - 01/2012
2	Solitary Kidney 05/2019 - 06/2011
2	Hypersensitivity (Allergy) 01/2019 - 01/2017
2	Carcinogenesis 01/2018 - 11/2010
2	Seminoma 01/2018 - 07/2008
2	Urinary Retention 09/2017 - 10/2009
2	Intraoperative Complications 01/2017 - 09/2009
2	Interstitial Cystitis (Interstitial Cystitis, Chronic) 01/2017 - 01/2016
2	Lymphatic Metastasis 05/2014 - 10/2012
2	Thrombosis (Thrombus) 04/2014 - 01/2012
2	Ischemia 11/2012 - 11/2010
2	Acute Kidney Injury (Acute Renal Failure) 10/2012 - 01/2008
2	Hyperplasia 09/2011 - 04/2011

Drug/Important Bio-Agent (IBA)

12	silodosin FDA Link 04/2021 - 12/2009
11	Cholinergic Antagonists (Anticholinergics)IBA 10/2017 - 01/2005
9	Prostate-Specific Antigen (Semenogelase)IBA 05/2020 - 02/2003
7	mirabegronIBA 08/2020 - 06/2014
6	Therapeutic UsesIBA 12/2020 - 10/2012
6	naftopidilIBA 01/2019 - 09/2005
6	Tamsulosin (Flomax)FDA LinkGeneric 10/2013 - 09/2005
5	Immune Checkpoint InhibitorsIBA 05/2024 - 03/2018
5	Tadalafil (Cialis)FDA Link 04/2021 - 01/2018
5	propiverineIBA 01/2018 - 09/2007
5	Solifenacin Succinate FDA Link 10/2015 - 09/2007
4	NivolumabIBA 05/2024 - 03/2018
4	AndrogensIBA 02/2021 - 04/2014
4	Docetaxel (Taxotere)FDA Link 02/2021 - 06/2018
4	N- (4- ((5- (hydroxy(phenyl)methyl)pyrrolidin- 2- yl)methyl)phenyl)- 4- oxo- 4,6,7,8- tetrahydropyrrolo(1,2- a)pyrimidine- 6- carboxamideIBA 01/2021 - 01/2018
4	Androgen Receptors (Androgen Receptor)IBA 11/2020 - 04/2014
4	Messenger RNA (mRNA)IBA 01/2018 - 07/2014
4	Folic Acid (Vitamin M)FDA LinkGeneric 02/2007 - 07/2003
3	2- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA 01/2023 - 01/2019
3	Testosterone (Sustanon)FDA Link 01/2022 - 02/2016
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2019 - 04/2014
3	Dutasteride (Avodart)FDA Link 10/2017 - 08/2014
2	AntibodiesIBA 06/2023 - 03/2018
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 03/2021 - 01/2021
2	TAS-303IBA 03/2021 - 01/2021
2	salicylhydroxamic acid (SHAM)IBA 08/2020 - 01/2017
2	fesoterodine FDA Link 01/2020 - 01/2019
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2019 - 03/2017
2	Muscarinic AntagonistsIBA 01/2019 - 09/2007
2	Vincristine (Oncovin)FDA LinkGeneric 01/2019 - 01/2018
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2018 - 01/2017
2	resiniferatoxinIBA 01/2018 - 01/2017
2	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2017 - 09/2005
2	Proteins (Proteins, Gene)FDA Link 01/2017 - 03/2015
2	Tyrosine Kinase InhibitorsIBA 10/2016 - 03/2014
2	Axitinib (AG 013736)IBA 10/2016 - 04/2014
2	Sorafenib (BAY 43-9006)FDA Link 04/2015 - 01/2012
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2015 - 04/2014
2	Eosine Yellowish-(YS) (Eosin)IBA 03/2015 - 04/2014
2	Hematoxylin (Haematoxylon)IBA 03/2015 - 04/2014
2	rebamipideIBA 12/2014 - 04/2014
2	Type A Botulinum Toxins (Botox)FDA Link 05/2013 - 06/2011

Therapy/Procedure

29	Therapeutics 05/2024 - 07/2011
19	Prostatectomy (Retropubic Prostatectomy) 07/2022 - 04/2003
14	Nephrectomy 01/2018 - 12/2003
7	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2021 - 01/2010
6	Nephroureterectomy 01/2021 - 03/2003
6	Castration 11/2020 - 03/2017
6	Drug Therapy (Chemotherapy) 01/2019 - 04/2014
4	Aftercare (After-Treatment) 01/2022 - 01/2018
4	Operative Time 04/2009 - 05/2002
3	Suburethral Slings (Tension-Free Vaginal Tape) 01/2021 - 06/2006
3	Radiotherapy 01/2018 - 11/2017
3	Catheters 09/2017 - 11/2002
3	Lasers (Laser) 01/2017 - 01/2005
2	Neoadjuvant Therapy 11/2022 - 05/2014
2	Lipectomy (Liposuction) 01/2021 - 03/2019
2	Blood Transfusion (Blood Transfusions) 11/2020 - 05/2002
2	Adjuvant Chemotherapy 12/2019 - 10/2012
2	Lymph Node Excision (Lymph Node Dissection) 11/2017 - 01/2017
2	Ligation 05/2011 - 04/2009